On-line Dropwise Analysis of Extraction Chromatography Resins

Notice ID:

BA-1105

Department/Ind. Agency:

ENERGY, DEPARTMENT OF

Sub-tier:

ENERGY, DEPARTMENT OF

Sub Command:

BATTELLE ENERGY ALLIANCE–DOE CNTR

Office:

BATTELLE ENERGY ALLIANCE–DOE CNTR

All Dates/Times are:

(UTC-04:00) EASTERN STANDARD TIME, NEW YORK, USA

Updated Published Date:

(UTC-04:00) EASTERN STANDARD TIME, NEW YORK, USA

Original Published Date:

2020-11-03 13:29:00

Original Response Date:

Nov 03, 2021

Inactive Policy:

15 days after date offers due

Original Inactive Date:

Nov 18, 2021

Initiative:

• None***--***

Product Service Code:

6695 - COMBINATION AND MISCELLANEOUS INSTRUMENTS

NAICS Code:

334516 - Analytical Laboratory Instrument Manufacturing

Original Set Aside:

TECHNOLOGY LICENSING OPPORTUNITY On-line Dropwise Analysis of Extraction Chromatography Resins Using the GPEC-MS liquid chromatography system for on-line dropwise separation analysis for more data in a fraction of the time. Opportunity: Idaho National Laboratory (INL), managed and operated by Battelle Energy Alliance, LLC (BEA), is offering the opportunity to enter into a license and/or collaborative research agreement to commercialize the dropwise separation analysis technique. Overview: Extraction chromatography resins are widely used in nuclear, geological, and environmental chemical analysis laboratories. INL’s Gas Pressurized Extraction Chromatograph (GPEC) furthers the applications of these resins by delivering a quantitative recovery of the liquid put into the system and microcolumn capabilities with high length-to-diameter ratios. Coupling the GPEC to a measurement instrument is difficult due to the separations being driven by pressurized gas, rather than by the peristaltic pumps that mass spectrometers rely on. Liquid chromatography-mass spectrometry (LC-MS) methods almost universally employ pumps rather than pressurized gas. This technology is a technique for connecting the GPEC, or another LC system, to a mass spectrometer (MS) while providing dropwise data. Description: This technology is the creation of an on-line drop collector, constructed entirely of common consumables, between the GPEC (or other LC system) and the MS. The drop collector’s simple construction allows for rapid replacement while providing limited carryover and shielding from environmental contamination. As drops leave the GPEC, they fall into this drop collector where they are drawn down and out into the mass spectrometer’s sample stream by a peristaltic pump. The resulting data gives results drop by drop, rather than fraction by fraction. Additionally, the incorporation of a flowing rinse between the GPEC and the mass spectrometer allows for dropwise resolution. Dropwise analysis also makes measurements on the highest concentration of analyte possible, resulting in higher signal-to-noise ratios during measurement that could be the difference between a quantifiable result or a qualitative one. This drop collection sample introduction technique could also be incorporated into other LC-MS systems or traditional drip columns. Benefits: Separation scheme development time is drastically decreased. Produces data that was previously impractical to obtain. Makes LC-MS analysis of small samples or low abundance analytes possible. Decreases the waste produced. Decreases costs of analysis in several areas. Simple construction allows for quick and easy replacement. Allows for validation of reusing columns without concerns of carryover, resulting in more complete separations while creating far less chemical waste. Applications: Separations and Mass Spectrometry Extraction Chromatography Nuclear Geological Environmental Development Status: TRL 4. System has been validated in laboratory environment. IP Status: US Provisional Patent Application No. 63/020,244, “Dropwise Separation Analysis and Tandem Column Capabilities of gas Pressurized Extraction Chromatography-Mass Spectrometry (GPEC-MS),” BEA Docket No. BA-1105. INL is seeking to license the above intellectual property to a company with a demonstrated ability to bring such inventions to the market. Exclusive rights in defined fields of use may be available. Companies interested in learning more about this licensing opportunity should contact Kala Majeti at td@inl.gov.

1955 N Fremont Avenue

Idaho Falls , ID 83415

USA

Primary Point of Contacts:

Andrew Rankin